MOTS-c
Mitochondrial-derived 16-amino acid peptide studied in metabolic and mitochondrial signaling research.
$70.00 – $180.00Price range: $70.00 through $180.00
- FormatLyophilized powder, single-use vial (10mg, 20mg, or 40mg)
- StorageStore lyophilized vial frozen; refer to COA for lot-specific stability data
MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA rather than the cell nucleus, making it part of a relatively uncommon class of…
About MOTS-c
MOTS-c is a short, 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene region. Research has investigated its role in AMPK signaling, glucose utilization, mitochondrial-nuclear communication, metabolic homeostasis, exercise-associated signaling, and age-related metabolic biology in preclinical models.
Full Specification
| Molecular Formula | C101H152N28O25S2 |
| Molecular Weight | 2174.64 g/mol |
| Purity | ≥99% (HPLC verified) |
| Appearance | White to off-white lyophilized powder |
| Storage | Store lyophilized vial frozen; refer to COA for lot-specific stability data |
| Format | Lyophilized powder, single-use vial (10mg, 20mg, or 40mg) |
The MOTS-c Molecule
An illustrative representation generated from the compound's molecular formula, alongside its logged molecular data. This figure is schematic — not a measured conformation.
How MOTS-c Works
The pathways MOTS-c acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
AMPK Activation
Energy-Sensing PathwayMOTS-c activates AMP-activated protein kinase (AMPK) in skeletal muscle, adipose tissue, and liver in preclinical models.
Mitochondria-to-Nucleus Signaling
mtDNA OriginMOTS-c is encoded in the mitochondrial 12S rRNA gene region and has been studied for nuclear translocation and regulation of antioxidant response element signaling.
Metabolic Homeostasis
Exercise-Associated SignalingMOTS-c has been studied in relation to exercise-associated metabolic responses, insulin sensitivity, energy metabolism, and mitochondrial biogenesis in preclinical models.
What MOTS-c Is Researched For
Insulin Sensitivity Models
Studied in high-fat diet mouse models for insulin sensitivity, fat accumulation, glucose tolerance, and skeletal muscle AMPK activation.
Age-Related Metabolic Decline
Studied in relation to age-associated changes in circulating MOTS-c, physical performance, and metabolic flexibility in animal models.
Exercise Mimicry
Studied in relation to exercise-associated energy metabolism, mitochondrial biogenesis markers, and endurance measures.
mtDNA Variation & Ageing Cohorts
MOTS-c sequence variants have been studied in population research examining metabolic markers and ageing.
Study-Reported Magnitudes
Representative figures from published research; results vary by protocol.
Certificate of Analysis
Every batch is tested by an accredited lab before it ships — here's the paperwork to prove it.
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Common Questions About MOTS-c
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene region and studied primarily in mitochondrial and metabolic research.
MOTS-c has been studied in relation to exercise-associated metabolic signaling, including energy metabolism, mitochondrial biogenesis markers, insulin sensitivity, and endurance measures in preclinical models.
Circulating MOTS-c levels have been reported to decline with age in humans and rodents, and the peptide is studied in the context of age-related metabolic decline and mitochondrial-nuclear communication.
Preclinical research has examined MOTS-c-associated AMPK activation, including AMPK phosphorylation in skeletal muscle and downstream metabolic signaling.
The supplied source mentions human research involving circulating MOTS-c levels, aerobic exercise, and population genetics, while several functional effects described on the page come from preclinical models.
The supplied specification lists -20°C for long-term stability. The listed form is lyophilized powder, with bacteriostatic water or sterile saline identified as solvents for research use.