5-Amino-1MQ
Small-molecule NNMT inhibitor studied in NAD+ metabolism, adipocyte metabolism, methyl donor regulation, and metabolic research.
$60.00
- FormatLyophilized Powder / 50 mg
- Storage-20°C, protect from light
5-Amino-1MQ is a small-molecule research compound rather than a peptide. It acts by inhibiting NNMT, an enzyme that uses nicotinamide, a precursor involved in…
50 in stock
About 5-Amino-1MQ
5-Amino-1MQ is a small-molecule competitive inhibitor of nicotinamide N-methyltransferase (NNMT). Research has examined NNMT inhibition in relation to nicotinamide availability, NAD+ salvage pathway activity, adipocyte energy metabolism, methyl donor pools, and metabolic signaling in preclinical models.
Full Specification
| Molecular Formula | C10H10N2 (CAS 4213-45-0) |
| Molecular Weight | 158.19 g/mol |
| Purity | ≥99% (HPLC verified) |
| Appearance | Orange Powder |
| Storage | -20°C, protect from light |
| Format | Lyophilized Powder / 50 mg |
The 5-Amino-1MQ Molecule
An illustrative representation generated from the compound's molecular formula, alongside its logged molecular data. This figure is schematic — not a measured conformation.
How 5-Amino-1MQ Works
The pathways 5-Amino-1MQ acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
Nicotinamide N-Methyltransferase Blockade
NNMT Inhibition5-Amino-1MQ acts as a small-molecule competitive inhibitor of NNMT, reducing nicotinamide methylation and altering methyl-group flux.
NAD+ Precursor Salvage Pathway Modulation
NAD+ MetabolismBy reducing NNMT-mediated consumption of nicotinamide, 5-Amino-1MQ redirects nicotinamide toward the NAD+ salvage pathway and has been associated with elevated intracellular NAD+.
Adipocyte Energy Metabolism
Adipocyte MetabolismNNMT inhibition with 5-Amino-1MQ has been studied in diet-induced obese mouse models in relation to white adipose tissue mass and adipocyte metabolic gene expression.
What 5-Amino-1MQ Is Researched For
Adipocyte & Metabolic Models
Studied in diet-induced obesity models in relation to white adipose tissue mass, energy expenditure, and adipocyte metabolism.
NAD+ Salvage Pathway
Studied for its ability to preserve nicotinamide availability for NAD+ biosynthesis through NNMT inhibition.
SAM Methyl Donor Pool
Studied in relation to NNMT consumption of S-adenosyl methionine and potential effects on methylation pathways.
Glucose Uptake Models
Studied in preclinical adipocyte models in relation to insulin sensitivity and glucose uptake markers.
Study-Reported Magnitudes
Representative figures from published research; results vary by protocol.
Common Questions About 5-Amino-1MQ
5-Amino-1MQ is a small-molecule competitive inhibitor of nicotinamide N-methyltransferase (NNMT) studied in preclinical metabolic research.
NNMT consumes nicotinamide, which is a precursor for NAD+ biosynthesis. Research has examined whether inhibiting NNMT redirects nicotinamide toward the NAD+ salvage pathway and increases intracellular NAD+.
Research has examined white adipose tissue mass, energy metabolism, adipocyte gene expression, and metabolic markers in diet-induced obese mouse models.
No. 5-Amino-1MQ is a small-molecule NNMT inhibitor, whereas NAD+ is a cellular coenzyme involved in energy metabolism and numerous enzymatic reactions.
The supplied source classifies 5-Amino-1MQ as research use only.
The supplied specification recommends storage at -20°C and protection from light.